Program in Cancer Neuroscience at Stanford

Glioma neuroscience

Venkatesh HS, Johung T, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Pollepalli J, Mitra SS, Woo PJ, Malenka RM, Vogel H, Bredel M, Mallick P, Monje M (2015) Neuronal activity promotes glioma growth through neuroligin-3 secretion, Cell, 161(4):803-16    

Venkatesh HS, Tam LT, Woo PJ, Nagaraja S, Gillespe SM, Lennon J, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M (2017) Targeting neuronal activity-regulated neuroligin-3 dependency for high-grade glioma, Nature 549: 533-537    

Nagaraja S, Vitanza N, Woo PJ, Taylor KR, Liu F, Zhang L, Li M, Meng W, Ponnuswami A, Sun W, Ma J, Hulleman E, Swigut T, Wysocka J, Tang Y, Monje M (2017) Transcriptional dependencies in diffuse intrinsic pontine glioma, Cancer Cell, 31(5):635-652    

Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, Tam LT, Espenel C, Ponnuswami A, Ni L, Woo PJ, Taylor KR, Agarwal A, Regev A, Brang D, Vogel H, Hervey-Jumper S, Bergles DE, Suvà ML, Malenka RC and Monje M (2019) Electrical and synaptic integration of glioma into neural circuits Nature 573: 539-545    

Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalcin B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Schaeffer S, Ma Y, Chang K-C, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg J, Monje M*, Gutmann DH* (2021) NF1 mutation drives neuronal activity-dependent optic glioma initiation. Nature. 594(7862):277-282

Cho KF, Gillespie SM, Kalogriopoulos NA, Quezada MA, Jacko M, Monje M, Ting AY. A light-gated transcriptional recorder for detecting cell-cell contacts. Elife. 2022 March 21;11:e70881

Lung Cancer Neuroscience 

Yang D, Qu F, Cai H, Chuang CH, Lim JS, Jahchan N, Grüner BM, S Kuo C, Kong C, Oudin MJ, Winslow MM, Sage J. Axon-like protrusions promote small cell lung cancer migration and metastasis.  Elife. 2019 Dec 13;8:e50616. doi: 10.7554/eLife.50616. PMID: 31833833

Cancer therapy-related cognitive impairment

Gibson E.M., Nagaraja S., Ocampo A, Tam L.T., Wood L.S., Pallegar P.N., Greene J.J., Geraghty A.C., Goldstein A.K., Ni. L., Woo P.J., Barres B.A., Liddelow S., Vogel H., Monje M. (2019) Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment, Cell, 176 (1), 43-55. NIHMS# 1510842

Geraghty A.C., Gibson E.M., Reem G., Greene J., Ocampo A., Goldstein A.K., Ni L., Yang T., Marton R.M., Pasca S.P., Greenberg M.E., Longo F.M., Monje M. (2019) Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment. Neuron, 103(2):250-265

Winkler F, Venkatesha HS, Amit M, Batchelor T, Demir IJ, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbot D, Platten M, Rolls A, Soan EK, Want TC, Wich W, Venkataramani V, Monje M. (2023)  Cancer neuroscience: State of the field, emerging directions. Cell 186(8) 1689-1707. doi.org/10.1016/j.cell.2023.02.002

Hanaham D, Monje M. (2023) Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell. 44(3) 573-580.  doi.org/10.1016/j.ccell.2023.02.012

 Keough, M.B., and Monje, M. (2022). Neural Signaling in Cancer. Annu Rev Neurosci.

Gibson EM and Monje M (2021) Microglia in cancer therapy-related cognitive impairment, Trends in Neurosciences, 44(6):441-451. doi: 10.1016/j.tins.2021.02.003

Monje M et al. (2020) Roadmap for the Emerging Field of Cancer Neuroscience, Cell, 181(2):219-222    

Gillespie S.M. and Monje M (2020) Neural Regulation of Cancer, Annual Review of Cancer Biology 4:371-390.

Monje M. (2020) Synaptic communication in brain cancer. Cancer Res. 80(14):2979-2982

Gibson EM and Monje M (2019) Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment. Curr Opin Oncol. 31(6):531-539